Various studies are being conducted on oncolytic virotherapy which one of the mechanisms
is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of …

Mammalian orthoreoviruses (ReoV) are non-enveloped viruses with segmented double-
stranded RNA genomes. In humans, ReoV are generally considered non-pathogenic …

Piscine orthoreovirus 1 (PRV-1) is the causative agent of heart and skeletal muscle
inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). The virus is widespread in …

The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host
relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of …

Mammalian orthoreovirus (reovirus) is a dsRNA virus, which has long been used as a model
system to study host–virus interactions. One of the earliest interactions during virus infection …

Piscine orthoreovirus-1 (PRV-1) can cause heart and skeletal muscle inflammation (HSMI)
in farmed Atlantic salmon (Salmo salar), but the line of events from infection, pathologic …

Mammalian orthoreovirus (MRV) outer capsid protein σ3 is a multifunctional protein
containing a double-stranded RNA-binding domain, which facilitates viral entry and …

Viruses as obligate intracellular parasites are limited by their small genome. They have thus
developed various strategies to maximize viral fitness with a limited amount of coding …

Oncolytic viruses are promising agents for cancer therapy because they selectively infect
and kill tumor cells, and because they trigger immune responses that can boost anticancer …

The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or
ADARs, is an essential post-transcriptional modification that contributes to proteome …