11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
[HTML][HTML] 7-Ketocholesterol in disease and aging
A Anderson, A Campo, E Fulton, A Corwin… - Redox biology, 2020 - Elsevier
Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …
Cholesterol oxidation products and their biological importance
The main biological cause of oxysterols is the oxidation of cholesterol. They differ from
cholesterol by the presence of additional polar groups that are typically hydroxyl, keto …
cholesterol by the presence of additional polar groups that are typically hydroxyl, keto …
Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
Oxysterols are structurally identical to cholesterol, but with one or more additional oxygen
containing functional groups (such as alcohol, carbonyl or epoxide groups). The wide array …
containing functional groups (such as alcohol, carbonyl or epoxide groups). The wide array …
[HTML][HTML] 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress
Glucocorticoids have profound effects on brain development and adult CNS function. Excess
or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The …
or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The …
Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands 2
The retinoic acid receptor-related orphan receptors α and γ (RORα (NR1F1) and RORγ
(NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of …
(NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of …
11β-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation
MS Cooper, PM Stewart - The Journal of Clinical Endocrinology …, 2009 - academic.oup.com
Context: 11β-Hydroxysteroid dehydrogenase (11β-HSD) enzymes are now appreciated to
be important regulators of hormone action at a tissue level. 11β-HSD1 is widely expressed …
be important regulators of hormone action at a tissue level. 11β-HSD1 is widely expressed …
Obesity and corticosteroids: 11β-Hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
NM Morton - Molecular and cellular endocrinology, 2010 - Elsevier
The metabolic abnormalities found associated with high blood glucocorticoid levels (eg rare
Cushing's syndrome) include insulin-resistance, visceral obesity, hypertension …
Cushing's syndrome) include insulin-resistance, visceral obesity, hypertension …
Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance
G Murdolo, M Piroddi, F Luchetti, C Tortoioli… - Biochimie, 2013 - Elsevier
Obesity has been proposed as an energy balance disorder in which the expansion of
adipose tissue (AT) leads to unfavorable health outcomes. Even though adiposity represents …
adipose tissue (AT) leads to unfavorable health outcomes. Even though adiposity represents …
Mass spectrometry imaging for dissecting steroid intracrinology within target tissues
Steroid concentrations within tissues are modulated by intracellular enzymes. Such “steroid
intracrinology” influences hormone-dependent cancers and obesity and provides targets for …
intracrinology” influences hormone-dependent cancers and obesity and provides targets for …