Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

The role of nutraceutical containing polyphenols in diabetes prevention

I Fernandes, J Oliveira, A Pinho, E Carvalho - Metabolites, 2022 - mdpi.com
Research in pharmacological therapy has led to the availability of many antidiabetic agents.
New recommendations for precision medicine and particularly precision nutrition may …

Design and evaluation of liposomal sulforaphane-loaded polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogels as a novel drug delivery system for wound …

H Hemati, F Haghiralsadat, M Hemati, G Sargazi… - Gels, 2023 - mdpi.com
Hydrogel scaffold has been widely applied as drug delivery systems for treating skin injuries.
However, the poor drug loading and rapid drug release of hydrogel restricted their …

Sulforaphane alleviated vascular remodeling in hypoxic pulmonary hypertension via inhibiting inflammation and oxidative stress

J Pan, R Wang, Y Pei, D Wang, N Wu, Y Ji… - The Journal of …, 2023 - Elsevier
Hypoxic pulmonary hypertension (HPH) is a cardiopulmonary disease featured by
pulmonary vascular remodeling, which is due to abnormal proliferation of pulmonary artery …

Mechanism of action and therapeutic effects of oxidative stress and stem cell-based materials in skin aging: Current evidence and future perspectives

H Qian, Y Shan, R Gong, D Lin, M Zhang… - … in Bioengineering and …, 2023 - frontiersin.org
Aging is associated with multiple degenerative diseases, including atherosclerosis,
osteoporosis, and Alzheimer's disease. As the most intuitive manifestation of aging, skin …

Interplay of broccoli/broccoli sprout bioactives with gut microbiota in reducing inflammation in inflammatory bowel diseases

J Holman, M Hurd, PL Moses, GM Mawe… - The Journal of nutritional …, 2023 - Elsevier
Abstract Inflammatory Bowel Diseases (IBD) are chronic, reoccurring, and debilitating
conditions characterized by inflammation in the gastrointestinal tract, some of which can …

Bifidobacterium longum CCFM1206 Promotes the Biotransformation of Glucoraphanin to Sulforaphane That Contributes to Amelioration of Dextran-Sulfate-Sodium …

J Wu, S Cui, X Tang, Q Zhang, Y Jin… - Journal of Agricultural …, 2023 - ACS Publications
Glucoraphanin, rich in broccoli seed extract (BSE), is generally inert but can be
biotransformed into active sulforaphane by gut bacteria. This study aimed to screen …

[HTML][HTML] Mangiferin Represses Inflammation in Macrophages Under a Hyperglycemic Environment Through Nrf2 Signaling

R Jayasuriya, K Ganesan, KM Ramkumar - International Journal of …, 2024 - mdpi.com
Inflammation in macrophages is exacerbated under hyperglycemic conditions, contributing
to chronic inflammation and impaired wound healing in diabetes. This study investigates the …

Steamed broccoli sprouts alleviate DSS-induced inflammation and retain gut microbial biogeography in mice

JM Holman, L Colucci, D Baudewyns, J Balkan… - Msystems, 2023 - Am Soc Microbiol
Inflammatory bowel diseases (IBDs) are devastating conditions of the gastrointestinal tract
with limited treatments, and dietary intervention may be effective and affordable for …

[HTML][HTML] Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells

D Bozic, K Živančević, K Baralić, EA Miljaković… - Biomedicine & …, 2023 - Elsevier
Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family.
It becomes bioactive after hydrolytic reaction mediated by myrosinase or human …