There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

Readers of this journal do not need to be re-minded of the explosive increase in obesity/type
2 diabetes syndromes and their attendant staggering public health costs that are currently …

Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …

In 1963, Lancet published a paper by Randle et al. that proposed a “glucose-fatty acid cycle”
to describe fuel flux between and fuel selection by tissues. The original biochemical …

Lipid metabolism is tightly controlled by the nutritional state of the organism. Nutrient-rich
conditions increase lipogenesis, whereas nutrient deprivation promotes fat oxidation. In this …

For decades, exercise has been consid-ered a cornerstone of diabetes management, along
with diet and medication. However, high-quality evidence on the importance of exercise and …

AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and
whole-body energy metabolism. We have identified a thienopyridone family of AMPK …

AMPK (AMP-activated protein kinase) is a phylogenetically conserved fuel-sensing enzyme
that is present in all mammalian cells. During exercise, it is activated in skeletal muscle in …