Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Different types of spiral ganglion neurons (SGNs) are essential for auditory perception by
transmitting complex auditory information from hair cells (HCs) to the brain. Here, we use …

Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract,
remodel their apical surface during differentiation to form a brush border: an array of actin …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

Myosins and kinesins are molecular motors that hydrolyse ATP to track along actin filaments
and microtubules, respectively. Although the kinesin family includes motors that move …

Autophagy targets pathogens, damaged organelles and protein aggregates for lysosomal
degradation. These ubiquitylated cargoes are recognized by specific autophagy receptors …

To understand how cells differentially use the dozens of myosin isozymes present in each
genome, we examined the distribution of four unconventional myosin isozymes in the inner …

DFNB3, a locus for nonsyndromic sensorineural recessive deafness, maps to a 3-
centimorgan interval on human chromosome 17p11. 2, a region that shows conserved …