Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Abstract Background The NaV1. 8 voltage-gated sodium channel, expressed in peripheral
nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548 …

Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …

Considerable progress has been made in identifying signaling pathways that direct the
differentiation of human pluripotent stem cells (hPSCs) into specialized cell types, including …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

The complete inability to sense pain in an otherwise healthy individual is a very rare
phenotype. In three consanguineous families from northern Pakistan, we mapped the …

This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic
metabolite methylglyoxal. We found that concentrations of plasma methylglyoxal above 600 …

Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-
function variants of sodium channel Nav1. 7 have recently been found in∼ 30% of cases of …

A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed
tissue. This results from the local release by immune and injured cells of nociceptor …