Clinical utility of viral load in management of cytomegalovirus infection after solid organ transplantation

RR Razonable, RT Hayden - Clinical microbiology reviews, 2013 - Am Soc Microbiol
The negative impact of cytomegalovirus (CMV) infection on transplant outcomes warrants
efforts toward improving its prevention, diagnosis, and treatment. During the last 2 decades …

Letermovir for the prevention of cytomegalovirus infection and disease in transplant recipients: an evidence-based review

G El Helou, RR Razonable - Infection and drug resistance, 2019 - Taylor & Francis
Cytomegalovirus (CMV) is a leading opportunistic infection in immune compromised
patients, including allogeneic hematopoietic stem cell (HSCT) or solid organ transplant …

[HTML][HTML] Cytomegalovirus in solid organ transplantation

RR Razonable, A Humar… - American journal of …, 2013 - Elsevier
Cytomegalovirus (CMV) is a ubiquitous herpes virus that infects the majority of humans (1).
The seroprevalence rates of CMV ranges from 30–97%(2, 3). Primary infection manifests as …

Letermovir for cytomegalovirus prophylaxis in hematopoietic-cell transplantation

RF Chemaly, AJ Ullmann, S Stoelben… - … England Journal of …, 2014 - Mass Medical Soc
Background Cytomegalovirus (CMV) infection is a leading cause of illness and death in
patients who have undergone allogeneic hematopoietic-cell transplantation. Available …

Antiviral prophylaxis for cytomegalovirus infection in allogeneic hematopoietic cell transplantation

K Chen, MP Cheng, SP Hammond, H Einsele… - Blood …, 2018 - ashpublications.org
Patients treated with allogeneic hematopoietic cell transplantation (HCT) are at risk of
cytomegalovirus (CMV) reactivation and disease, which results in increased morbidity and …

The human cytomegalovirus terminase complex as an antiviral target: a close-up view

G Ligat, R Cazal, S Hantz, S Alain - FEMS microbiology reviews, 2018 - academic.oup.com
Human cytomegalovirus (HCMV) is responsible for life-threatening infections in
immunocompromised individuals and can cause serious congenital malformations …

New therapies for human cytomegalovirus infections

WJ Britt, MN Prichard - Antiviral research, 2018 - Elsevier
The recent approval of letermovir marks a new era of therapy for human cytomegalovirus
(HCMV) infections, particularly for the prevention of HCMV disease in hematopoietic stem …

Use of letermovir as salvage therapy for drug-resistant cytomegalovirus retinitis

N Turner, A Strand, DS Grewal, G Cox… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a
novel antiviral recently approved for CMV prophylaxis following hematopoietic cell …

Preemptive treatment of Cytomegalovirus infection in kidney transplant recipients with letermovir: results of a Phase 2a study

S Stoelben, W Arns, L Renders, J Hummel… - Transplant …, 2014 - Wiley Online Library
Cytomegalovirus (CMV) infection remains a significant cause of morbidity and mortality in
transplant recipients. Letermovir (AIC 246), is a novel anti‐HCMV drug in development …

Clinical development of letermovir and maribavir: Overview of human cytomegalovirus drug resistance

J Piret, G Boivin - Antiviral research, 2019 - Elsevier
The prevention and treatment of human cytomegalovirus (HCMV) infections is based on the
use of antiviral agents that currently target the viral DNA polymerase and that may cause …