Introduction Variants in the leucine-rich repeat kinase 2 gene (LRRK2) are risk factors for
Parkinson's disease (PD), but their prevalence varies geographically, reflecting the locations …

Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have
taken place predominantly in European populations. Recent genetics research conducted in …

Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia
faces pressing challenges, such as heterogeneity, diversity, political instability, and …

Objective This work was undertaken in order to identify Parkinson's disease (PD) risk
variants in a Latino cohort, to describe the overlap in the genetic architecture of PD in …

Neuromelanin‐containing dopaminergic neurons in the substantia nigra pars compacta
(SNpc) are the most vulnerable neurons in Parkinson's disease (PD). Recent work suggests …

Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal
vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in …

Background Identifying hereditary parkinsonism is valuable for diagnosis, genetic
counseling, patient prioritization in trials, and studying the disease for personalized …

Background Parkinson's disease (PD) is a rapidly growing neurodegenerative disorder, but
up‐to‐date epidemiological data are lacking in Latin America. We sought to estimate the …

Genetics and genomics in Peru: Clinical and research perspective - PMC Back to Top Skip to
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Parkinson's disease (PD) research has historically neglected the study of diverse
populations, and the field as a whole has suffered as a result. By failing to address PD …