The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Alzheimer's disease is the most common form of age-related neurodegenerative dementia.
The disease is characterised by the presence of plaques in the cerebral cortex. The major …

Dysfunctional interaction of amyloid-β (Aβ) with excess metal ions is proved to be related to
the etiology of Alzheimer's disease (AD). Hence, disruption of these metal-peptide …

Exploring the dynamic structural evolution of electrocatalysts during reactions represents a
fundamental objective in the realm of electrocatalytic mechanism research. In pursuit of this …

Stereochemistry is a very important issue for the pharmaceutical industry and can determine
drug efficacy. The design and synthesis of small molecules, especially chiral molecules …

Alzheimer's disease (AD) is the most common form of dementia, and is a multi-faceted
disease that is characterized by oxidative stress, metal-ion dysregulation, and the formation …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Alzheimer's disease (AD) is the most common form of dementia, where one of the
pathological hallmarks of AD is extracellular protein deposits, the primary component of …

Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …

Stereochemistry is vital for pharmaceutical development and can determine drug efficacy.
Herein, 10 pairs of asymmetric triplex metallohelix enantiomers as a library were used to …