[HTML][HTML] Glutamatergic mechanisms in glioblastoma and tumor-associated epilepsy

F Lange, MF Hörnschemeyer, T Kirschstein - Cells, 2021 - mdpi.com
The progression of glioblastomas is associated with a variety of neurological impairments,
such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of …

OBSERVE: guidelines for the refinement of rodent cancer models

SI De Vleeschauwer, M van de Ven, A Oudin… - Nature …, 2024 - nature.com
Existing guidelines on the preparation (Planning Research and Experimental Procedures on
Animals: Recommendations for Excellence (PREPARE)) and reporting (Animal Research …

Converging mechanisms of epileptogenesis and their insight in glioblastoma

KE Hills, K Kostarelos, RC Wykes - Frontiers in molecular …, 2022 - frontiersin.org
Glioblastoma (GBM) is the most common and advanced form of primary malignant tumor
occurring in the adult central nervous system, and it is frequently associated with epilepsy, a …

The Role of Aquaporins in Epileptogenesis—A Systematic Review

L Bonosi, UE Benigno, S Musso, K Giardina… - International Journal of …, 2023 - mdpi.com
Aquaporins (AQPs) are a family of membrane proteins involved in the transport of water and
ions across cell membranes. AQPs have been shown to be implicated in various …

A novel prognostic tool for glioma based on enhancer RNA-regulated immune genes

W Tian, K Chen, G Yan, X Han, Y Liu… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Gliomas are the most malignant tumors of the nervous system. Even though
their survival outcome is closely affected by immune-related genes (IRGs) in the tumor …

From bedside to bench: new insights in epilepsy‐associated tumors based on recent classification updates and animal models on brain tumor networks

S Cases‐Cunillera, LL Friker, P Müller… - Molecular …, 2024 - Wiley Online Library
Low‐grade neuroepithelial tumors (LGNTs), particularly those with glioneuronal histology,
are highly associated with pharmacoresistant epilepsy. Increasing research focused on …

Integrating and optimizing tonabersat in standard glioblastoma therapy: A preclinical study

V Zoteva, V De Meulenaere, C Vanhove, L Leybaert… - Plos one, 2024 - journals.plos.org
Glioblastoma (GB), a highly aggressive primary brain tumor, presents a poor prognosis
despite the current standard therapy, including radiotherapy and temozolomide (TMZ) …

Eslicarbazepine induces apoptosis and cell cycle arrest in C6 glioma cells in vitro and suppresses tumor growth in an intracranial rat model

N Afsordeh, S Pournajaf, H Bayat, F Mohajerani… - BMC cancer, 2024 - Springer
Background Glioblastoma multiforme (GBM) is the most malignant brain tumor, with a poor
prognosis and life expectancy of 14–16 months after diagnosis. The standard treatment for …

Thrombospondin-2 promotes the proliferation and migration of glioma cells and contributes to the progression of glioma

TL Huang, YW Mei, Y Li, X Chen, SX Yu… - Chinese …, 2023 - mednexus.org
Background: Gliomas, especially high-grade gliomas, are highly malignant with a poor
prognosis. Although existing treatments have improved the survival rate of patients with …

Comparison of in vivo and ex vivo magnetic resonance imaging in a rat model for glioblastoma-associated epilepsy

C Bouckaert, E Christiaen, J Verhoeven, B Descamps… - Diagnostics, 2021 - mdpi.com
Magnetic resonance imaging (MRI) is frequently used for preclinical treatment monitoring in
glioblastoma (GB). Discriminating between tumors and tumor-associated changes is …