ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter …

Background The widespread use of antibiotics plays a major role in the development and
spread of antimicrobial resistance. However, important knowledge gaps still exist regarding …

Background Inappropriate antibiotic use greatly accelerates antimicrobial resistance. The
appropriateness of antibiotic prescriptions is well evaluated, using big observational data, in …

Importance Nonguideline antibiotic prescribing for the treatment of pediatric infections is
common, but the consequences of inappropriate antibiotics are not well described. Objective …

The proportion of antibiotic prescriptions prescribed in US physician offices and emergency
departments that were unnecessary decreased slightly, from 30% in 2010–2011 to 28% in …

Intestinal host-microbiota interactions during the first year of life are critical for infant
development. Early-life antibiotic exposures disrupt stereotypical gut microbiota maturation …

Importance Antibiotic overuse contributes to adverse drug effects, increased costs, and
antimicrobial resistance. Objective To evaluate peer-comparison audit and feedback to high …

Importance Low-value care, defined as care offering no net benefit in specific clinical
scenarios, is associated with harmful outcomes in patients and wasteful spending. Despite a …

BACKGROUND: Off-label drug use in children is common and potentially harmful. In most
previous off-label use research, authors studied hospitalized children, specific drug classes …

Importance Although fluoroquinolones are commonly prescribed antibiotics in the US, recent
international studies have shown an increased risk of aortic aneurysm and dissection after …