Eukaryotic transcription factors activate gene expression with their DNA-binding domains
and activation domains. DNA-binding domains bind the genome by recognizing structurally …

The vertebrate retina is made up of six specialized neuronal cell types and one glia that are
generated from a common retinal progenitor. The development of these distinct cell types is …

Gene expression in Arabidopsis is regulated by more than 1,900 transcription factors (TFs),
which have been identified genome-wide by the presence of well-conserved DNA-binding …

Transcription factors can promote gene expression through activation domains. Whole-
genome screens have systematically mapped activation domains in transcription factors but …

Transcriptional activation domains (ADs) of gene activators have remained enigmatic for
decades as short, extremely variable, and structurally disordered sequences. Using a …

A properly organized subcellular composition is essential to cell function. The canonical
organizing principle within eukaryotic cells involves membrane-bound organelles; yet, such …

Sequence-specific activation by transcription factors is essential for gene regulation 1, 2.
Key to this are activation domains, which often fall within disordered regions of transcription …

Intrinsically disordered regions (IDRs) are critical for a wide variety of cellular functions,
many of which involve interactions with partner proteins. Molecular recognition is typically …

The phosphate-starvation response transcription-factor protein family is essential to plant
response to low-levels of phosphate. Proteins in this transcription factor (TF) family act by …

Laboratory-engineered proteins such as high-fidelity DNA polymerases, CRISPR base and
prime editors, and chimeric antigen receptors have transformed our ability to probe and …