Hyperpolarization-activated cation channels: from genes to function
M Biel, C Wahl-Schott, S Michalakis… - Physiological …, 2009 - journals.physiology.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …
Neurophysiology of HCN channels: from cellular functions to multiple regulations
C He, F Chen, B Li, Z Hu - Progress in neurobiology, 2014 - Elsevier
Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …
involved in multiple physiological processes.•HCN channels are excellent targets of various …
Anionic lipids unlock the gates of select ion channels in the pacemaker family
PAM Schmidpeter, D Wu, J Rheinberger… - Nature structural & …, 2022 - nature.com
Lipids play important roles in regulating membrane protein function, but the molecular
mechanisms used are elusive. Here we investigated how anionic lipids modulate SthK, a …
mechanisms used are elusive. Here we investigated how anionic lipids modulate SthK, a …
Exploring HCN channels as novel drug targets
O Postea, M Biel - Nature reviews Drug discovery, 2011 - nature.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …
Actions and mechanisms of polyunsaturated fatty acids on voltage-gated ion channels
Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant
physiological and pharmacological effects. In this review we summarize data from numerous …
physiological and pharmacological effects. In this review we summarize data from numerous …
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives
S Incontro, ML Musella, M Sammari… - Physiological …, 2025 - journals.physiology.org
Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
Corticotropin‐releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C‐dependent enhancement of Ih
Stress induces the release of the peptide corticotropin‐releasing factor (CRF) into the ventral
tegmental area (VTA), and also increases dopamine levels in brain regions receiving dense …
tegmental area (VTA), and also increases dopamine levels in brain regions receiving dense …
The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels
L Sartiani, G Mannaioni, A Masi, MN Romanelli… - Pharmacological …, 2017 - Elsevier
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …
members of the voltage-gated pore loop channels family. They show unique features: they …
Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy
Ion channelopathy plays an important role in human epilepsy with a genetic cause and has
been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired …
been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired …
GABAB receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels
PY Deng, Z Xiao, C Yang, L Rojanathammanee… - Neuron, 2009 - cell.com
The entorhinal cortex (EC) is regarded as the gateway to the hippocampus and thus is
essential for learning and memory. Whereas the EC expresses a high density of GABA B …
essential for learning and memory. Whereas the EC expresses a high density of GABA B …