Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet

DC Willcox, G Scapagnini, BJ Willcox - Mechanisms of ageing and …, 2014 - Elsevier
The traditional diet in Okinawa is anchored by root vegetables (principally sweet potatoes),
green and yellow vegetables, soybean-based foods, and medicinal plants. Marine foods …

Estimates of the heritability of human longevity are substantially inflated due to assortative mating

JG Ruby, KM Wright, KA Rand, A Kermany, K Noto… - Genetics, 2018 - academic.oup.com
Here, Ruby et al. analyze an unprecedented amount of public family tree data from Ancestry
and determine that the heritability of human longevity was well below 10%, lower than the …

MicroRNA Predictors of Longevity in Caenorhabditis elegans

Z Pincus, T Smith-Vikos, FJ Slack - PLoS genetics, 2011 - journals.plos.org
Neither genetic nor environmental factors fully account for variability in individual longevity:
genetically identical invertebrates in homogenous environments often experience no less …

A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals

A Nebel, R Kleindorp, A Caliebe, M Nothnagel… - Mechanisms of ageing …, 2011 - Elsevier
We conducted a case–control genome-wide association study (GWAS) of human longevity,
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

N van den Berg, M Rodríguez-Girondo… - Nature …, 2019 - nature.com
Survival to extreme ages clusters within families. However, identifying genetic loci conferring
longevity and low morbidity in such longevous families is challenging. There is debate …

Aging biomarkers: from functional tests to multi‐omics approaches

KS Kudryashova, K Burka, AY Kulaga… - …, 2020 - Wiley Online Library
Aging results in various deleterious changes in the human body that may lead to loss of
function and the manifestation of chronic diseases. While diseases can generally be reliably …

Biomarkers of aging

Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

[HTML][HTML] Historical demography and longevity genetics: back to the future

N van den Berg, M Beekman, KR Smith… - Ageing research …, 2017 - Elsevier
Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results

C Pattaro, M Gögele, D Mascalzoni, R Melotti… - Journal of Translational …, 2015 - Springer
Abstract The Cooperative Health Research In South Tyrol (CHRIS) study is a population-
based study with a longitudinal lookout to investigate the genetic and molecular basis of age …