UDP-glycosyltransferases (UGTs) are major phase II enzymes of a detoxification system
evolved in all kingdoms of life. Lipophilic endobiotics such as hormones and xenobiotics …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

This work revises and complements existing findings on the distribution of drug‐
metabolizing enzymes in the first‐pass effect organs. We explored gene expression …

Variability in individual capacity for hepatic elimination of therapeutic drugs is well
recognized and is associated with variable expression and activity of liver enzymes and …

BACKGROUND UDP–glycosyltransferases (UGTs) are phase II detoxification enzymes
widely distributed within living organisms. Their involvement in the biotransformation of …

Many different methods are used for mass-spectrometry-based protein quantification in
pharmacokinetics and systems pharmacology. It has not been established to what extent the …

Freshly isolated human hepatocytes are considered the gold standard for in vitro studies of
liver functions, including drug transport, metabolism, and toxicity. For accurate predictions of …

There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of
medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing) …

To predict the impact of liver cirrhosis on hepatic drug clearance using physiologically based
pharmacokinetic (PBPK) modeling, we compared the protein abundance of various phase 1 …

Population factors such as age, gender, ethnicity, genotype and disease state can cause
inter-individual variability in pharmacokinetic (PK) profile of drugs. Primarily, this variability …