Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as
frequent in patients with diabetes compared with those who do not have diabetes. Moreover …

Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …

Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

Background Recent studies highlight the role of metabolites in immune diseases, but it
remains unknown how much of this effect is driven by genetic and non-genetic host factors …

We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …

Metabolome reflects the interplay of genome and exposome at molecular level and thus can
provide deep insights into the pathogenesis of a complex disease like major depression. To …

Objectives Nuclear magnetic resonance (NMR) metabolomics is high throughput and cost-
effective, with the potential to improve the understanding of disease and risk. We examine …

Genetic studies of metabolites have identified thousands of variants, many of which are
associated with downstream metabolic and obesogenic disorders. However, these studies …

Here we examine the association between DNA methylation in circulating leukocytes and
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …

Over the last decade, immunometabolism has emerged as a novel interdisciplinary field of
research and yielded significant fundamental insights into the regulation of immune …