Benchmarking transcriptional host response signatures for infection diagnosis
DG Chawla, A Cappuccio, A Tamminga, SC Sealfon… - Cell Systems, 2022 - cell.com
Identification of host transcriptional response signatures has emerged as a new paradigm
for infection diagnosis. For clinical applications, signatures must robustly detect the …
for infection diagnosis. For clinical applications, signatures must robustly detect the …
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections
J Rosenheim, RK Gupta, C Thakker, T Mann… - Nature …, 2024 - nature.com
Blood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon
(IFN) signalling, but it is not known whether there are biological differences in their …
(IFN) signalling, but it is not known whether there are biological differences in their …
SARS-CoV-2 human challenge reveals single-gene blood transcriptional biomarkers that discriminate early and late phases of acute respiratory viral infections
J Rosenheim, RK Gupta, C Thakker, T Mann, LCK Bell… - medRxiv, 2023 - medrxiv.org
Evaluation of host-response blood transcriptional signatures of viral infection have so far
failed to test whether these biomarkers reflect different biological processes that may be …
failed to test whether these biomarkers reflect different biological processes that may be …
Epigenetic and transcriptional responses in circulating leukocytes are associated with future decompensation during SARS-CoV-2 infection
To elucidate host response elements that define impending decompensation during SARS-
CoV-2 infection, we enrolled subjects hospitalized with COVID-19 who were matched for …
CoV-2 infection, we enrolled subjects hospitalized with COVID-19 who were matched for …
A Multi-Machine Learning Consensus Model Based on Clinical Features Reveals That Interleukin-10 Derived from Monocytes Leads to a Poor Prognosis in Patients …
J Yu, Y Zhang, Z Ye, K Tang, Y Ma, L Fu… - Journal of …, 2024 - Taylor & Francis
Background Despite ongoing interventions, SARS-CoV-2 continues to cause significant
global morbidity and mortality. Early diagnosis and intervention are crucial for effective …
global morbidity and mortality. Early diagnosis and intervention are crucial for effective …