The blood-brain barrier in health and chronic neurodegenerative disorders

BV Zlokovic - Neuron, 2008 - cell.com
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers

EV Batrakova, AV Kabanov - Journal of controlled release, 2008 - Elsevier
Polymer nanomaterials have sparked a considerable interest as vehicles used for diagnostic
and therapeutic agents; research in nanomedicine has not only become a frontier movement …

Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders

H Qosa, DS Miller, P Pasinelli, D Trotti - Brain research, 2015 - Elsevier
The strength of the blood-brain barrier (BBB) in providing protection to the central nervous
system from exposure to circulating chemicals is maintained by tight junctions between …

Involvement of the low‐density lipoprotein receptor‐related protein in the transcytosis of the brain delivery vector Angiopep‐2

M Demeule, JC Currie, Y Bertrand… - Journal of …, 2008 - Wiley Online Library
The blood–brain barrier (BBB) restricts the entry of proteins as well as potential drugs to
cerebral tissues. We previously reported that a family of Kunitz domain‐derived peptides …

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

W Löscher, H Potschka - Progress in neurobiology, 2005 - Elsevier
The blood–brain barrier (BBB) serves as a protective mechanism for the brain by preventing
entry of potentially harmful substances from free access to the central nervous system …

Brain endothelial cells and the glio-vascular complex

H Wolburg, S Noell, A Mack, K Wolburg-Buchholz… - Cell and tissue …, 2009 - Springer
We present and discuss the role of endothelial and astroglial cells in managing the blood-
brain barrier (BBB) and aspects of pathological alterations in the BBB. The impact of …

Physiological and pathological roles of caveolins in the central nervous system

J Badaut, C Blochet, A Obenaus, L Hirt - Trends in neurosciences, 2024 - cell.com
Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft
invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are …

In situ localization of P-glycoprotein (ABCB1) in human and rat brain

R Bendayan, PT Ronaldson… - … of Histochemistry & …, 2006 - journals.sagepub.com
Transport of several xenobiotics including pharmacological agents into or out of the central
nervous system (CNS) involves the expression of ATP-dependent, membrane-bound efflux …

Chronic cerebrovascular dysfunction after traumatic brain injury

A Jullienne, A Obenaus, A Ichkova… - Journal of …, 2016 - Wiley Online Library
Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long‐term
alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form …

Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport

G Sahay, EV Batrakova, AV Kabanov - Bioconjugate chemistry, 2008 - ACS Publications
Efficient entry of synthetic polymers inside cells is a central issue in polymeric drug delivery.
Though polymers are widely believed to interact nonspecifically with plasma membrane, we …