Molecular mechanisms underlying neuroinflammation elicited by occupational injuries and toxicants

D Pathak, K Sriram - International Journal of Molecular Sciences, 2023 - mdpi.com
Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

Inflammation in traumatic brain injury

TT Postolache, A Wadhawan, A Can… - Journal of …, 2020 - content.iospress.com
There is an increasing evidence that inflammation contributes to clinical and functional
outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing …

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

H Abou-El-Hassan, RM Rezende, S Izzy… - Nature …, 2023 - nature.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …

Amplified gliosis and interferon-associated inflammation in the aging brain following diffuse traumatic brain injury

LM Wangler, CE Bray, JM Packer, ZM Tapp… - Journal of …, 2022 - Soc Neuroscience
Traumatic brain injury (TBI) is associated with chronic psychiatric complications and
increased risk for development of neurodegenerative pathology. Aged individuals account …

[PDF][PDF] An update on the rod microglia variant in experimental and clinical brain injury and disease

KR Giordano, CR Denman, PS Dubisch… - Brain …, 2021 - academic.oup.com
Contemporary microglia morphologies include ramified, activated and amoeboid, with the
morphology of microglia considered highly coupled to the cellular function. Rod microglia …

Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds

BR Lins, CC Anyaegbu, SC Hellewell, M Papini… - Journal of …, 2023 - Springer
Traumatic brain injury is common, and often results in debilitating consequences. Even mild
traumatic brain injury leaves approximately 20% of patients with symptoms that persist for …

Cannabidiol's neuroprotective properties and potential treatment of traumatic brain injuries

MM Aychman, DL Goldman, JS Kaplan - Frontiers in neurology, 2023 - frontiersin.org
Cannabidiol (CBD) has numerous pharmacological targets that initiate anti-inflammatory,
antioxidative, and antiepileptic properties. These neuroprotective benefits have generated …

Inhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut–liver–brain axis: an experimental and bioinformatic study

A Sepehrinezhad, A Shahbazi, MT Joghataei… - Cell death & …, 2023 - nature.com
There is accumulating evidence that the circulatory levels of autotaxin (ATX) and
lysophosphatidic acid (LPA) are increased in patients with severe liver disease. However …

Cell-derived exosomes as therapeutic strategies and exosome-derived microRNAs as biomarkers for traumatic brain injury

J Wang, J Wang, X Li, K Shu - Journal of Clinical Medicine, 2022 - mdpi.com
Traumatic brain injury (TBI) is a complex, life-threatening condition that causes mortality and
disability worldwide. No effective treatment has been clinically verified to date. Achieving …

The immune system's role in the consequences of mild traumatic brain injury (concussion)

LN Verboon, HC Patel, AD Greenhalgh - Frontiers in immunology, 2021 - frontiersin.org
Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common
form of TBI and affects millions of people each year. A history of mild TBI increases the risk of …