The success of inhibitor-based therapeutics is largely constrained by the acquisition of
therapeutic resistance, which is partially driven by the undruggable proteome. The …

Macrophage migration inhibitory factor (MIF) is a cytokine in the immune system,
participated in both innate and adaptive immune responses. Except from immune cells, MIF …

GBM is the most common, aggressive, and intracranial primary brain tumor; it originates from
the glial progenitor cells, has poor overall survival (OS), and has limited treatment options. In …

MIF/CD74 signaling pathway and autophagy may be closely related to liver fibrosis. Vanillic
acid (VA) is likely to have an anti-liver fibrosis effect, although related studies have not been …

Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and essential
signaling protein associated with inflammation and cancers. One of the newly described …

The role of macrophage migration inhibitory factor (MIF) as a multifunctional cytokine in
immunomodulation and inflammatory response is increasingly appreciated. Ischemic heart …

Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the
vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed …

The Mediterranean Diet (MedDiet) is associated with beneficial effects against chronic non-
communicable diseases (CNCDs). In particular, the content of micronutrients leads to an …

Endometriosis (EMS) is a common gynecological disease. Prostaglandin E2 (PGE2), which
induces chronic pelvic inflammation and cell pyroptosis, a form of programmed cell death …

Background Pancreatic ductal adenocarcinoma (PDAC) is an extremely deadly neoplasm,
with only a 5-year survival rate of around 9%. The tumor and its microenvironment are highly …