Zinc is crucial for physiological processes; however, deficiency persists globally. Binding
zinc to plant proteins enhances absorption, minimizing toxicity risks and offering a potential …

There is an urgent need for new antibiotics given the rise of antibiotic resistance, and
succinyl-diaminopimelate desuccinylase (DapE, EC 3.5. 1.18) has emerged as a promising …

Growing antibiotic resistance by pathogenic bacteria has led to a global crisis. The bacterial
enzyme N-succinyl-l, l-diaminopimelic acid desuccinylase (DapE) provides a very attractive …

The microbial enzyme diaminopimelate epimerase (DapF), a vital enzyme in the lysine
biosynthetic pathway, catalyzes the conversion of l, l-diaminopimelate (l, l-DAP) to d, l …

The microbial aminotransferase enzyme DapC is vital for lysine biosynthesis in various
Gram-positive bacteria, including Mycobacterium tuberculosis. Characterization of the …

Based on the inhibitory potencies from earlier reported tetrazole thioether analogs, we now
describe the synthesis and inhibition of pyrazole-based inhibitors of N-succinyl-l, l-2, 6 …

Based on our previous success in using cyclobutanone derivatives as enzyme inhibitors, we
have designed and prepared a 37-member library of α-aminocyclobutanone amides and …

The evolutionary relationship between arginine and lysine biosynthetic pathways has been
well established in bacteria and hyperthermophilic archaea but remains largely unknown in …

The global emergence of multidrug-resistant Acinetobacter species has become a major
concern in the management of hospital-acquired infections. Moreover, misdiagnosis of one …

Aquaculture holds immense promise for addressing the food needs of our growing global
population. Yet, a quantitative understanding of the factors that control its efficiency and …