The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …

Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

The motor cortex controls skilled arm movement by sending temporal patterns of activity to
lower motor centres. Local cortical dynamics are thought to shape these patterns throughout …

Activity in the motor cortex predicts movements, seconds before they are initiated. This
preparatory activity has been observed across cortical layers, including in descending …

Many human spinal cord injuries are anatomically incomplete but exhibit complete paralysis.
It is unknown why spared axons fail to mediate functional recovery in these cases. To …

Current models of somatosensory perception emphasize transmission from primary sensory
neurons to the spinal cord and on to the brain,,–. Mental influence on perception is largely …

Axonal regeneration in the central nervous system (CNS) is a highly energy-demanding
process. Extrinsic insults and intrinsic restrictions lead to an energy crisis in injured axons …

Little is known about the organizational and functional connectivity of the corticospinal (CS)
circuits that are essential for voluntary movement. Here, we map the connectivity between …

The brainstem is a key centre in the control of body movements. Although the precise nature
of brainstem cell types and circuits that are central to full-body locomotion are becoming …