Metallothioneins (MTs), low molecular mass cysteine-rich proteins, which are able to bind up
to 20 monovalent and up to 7 divalent heavy metal ions are widely studied due to their …

Metallothioneins (MTs) belong to a group of small cysteine-rich proteins that are ubiquitous
throughout all kingdoms. The main function of MTs is scavenging of free radicals and …

Patients with ependymoma exhibit a wide range of clinical outcomes that are currently
unexplained by clinical or histological factors. Little is known regarding molecular …

Abnormal spindle‑like microcephaly‑associated (ASPM) protein is essential for mitotic
spindle function during cell replication. The present study aimed to evaluate the hypothesis …

Better understanding of ependymoma (EPN) biology at relapse is needed to improve
therapy at this critical event. Convincing data exist defining transcriptionally distinct posterior …

Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy
development. Here, we used a tunable three-dimensional (3D) culture system to …

Several laboratories have described the existence of undifferentiated precursor cells that
may act like stem cells in the ependyma of the rodent spinal cord. However, there are reports …

Background Medulloblastoma, ependymoma, and pilocytic astrocytoma are common
pediatric posterior fossa tumors. These tumors show overlapping characteristics on …

We present here a novel surface mass spectrometry strategy to perform untargeted
metabolite profiling of formalin-fixed paraffin-embedded pediatric ependymoma archives …

Brain tumors are the leading cause of cancer death in children, with ependymoma being the
third most common and posing a significant clinical burden. Its mechanism of pathogenesis …