How to train your dragon: harnessing gamma delta T cells antiviral functions and trained immunity in a pandemic era

J Caron, LA Ridgley, M Bodman-Smith - Frontiers in immunology, 2021 - frontiersin.org
The emergence of viruses with pandemic potential such as the SARS-CoV-2 coronavirus
causing COVID-19 poses a global health challenge. There is remarkable progress in …

Training vs. Tolerance: the yin/yang of the innate immune system

T Lajqi, N Köstlin-Gille, R Bauer, SG Zarogiannis… - Biomedicines, 2023 - mdpi.com
For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns

BMN Kagina, B Abel, TJ Scriba, EJ Hughes… - American journal of …, 2010 - atsjournals.org
Rationale: Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by
measuring the frequency and cytokine expression profile of T cells. Objectives: We tested …

BCG vaccination induces innate immune memory in γδ T cells in humans

TK Suen, SJ Moorlag, W Li, LCJ de Bree… - Journal of Leukocyte …, 2024 - academic.oup.com
Abstract Bacillus Calmette–Guérin vaccine is well known for inducing trained immunity in
myeloid and natural killer cells, which can explain its cross-protective effect against …

Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth

M Papadopoulou, T Dimova, M Shey… - Proceedings of the …, 2020 - National Acad Sciences
Vγ9Vδ2 T cells are a major human blood γδ T cell population that respond in a T cell
receptor (TCR)-dependent manner to phosphoantigens which are generated by a variety of …

γδ T Cells Cross‐Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection

S Meraviglia, S El Daker, F Dieli… - Journal of …, 2011 - Wiley Online Library
Protective immunity against mycobacterial infections such as Mycobacterium tuberculosis is
mediated by interactions between specific T cells and activated antigen presenting cells. To …

The contribution of non-conventional T cells and NK cells in the mycobacterial-specific IFNγ response in Bacille Calmette-Guérin (BCG)-immunized infants

C Zufferey, S Germano, B Dutta, N Ritz, N Curtis - PloS one, 2013 - journals.plos.org
Background The Mycobacterium bovis Bacille Calmette-Guérin (BCG) vaccine is given to>
120 million infants each year worldwide. Most studies investigating the immune response to …

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

P Ruibal, L Voogd, SA Joosten… - Immunological …, 2021 - Wiley Online Library
Vaccination strategies against mycobacteria, focusing mostly on classical T‐and B‐cells,
have shown limited success, encouraging the addition of alternative targets. Classically …

The efficacy of topical intralesional BCG‐PSN injection in the treatment of erosive oral lichen planus: a randomized controlled trial

C Xiong, Q Li, M Lin, X Li, W Meng, Y Wu… - Journal of oral …, 2009 - Wiley Online Library
Background: Nowadays, it has been widely accepted that the local cell‐mediated
immunologic disorders may play an important role in the pathogenesis of oral lichen planus …

Impaired bacillus Calmette–Guérin cellular immune response in HIV-exposed, uninfected infants

TN Mazzola, MTN da Silva, BM Abramczuk… - Aids, 2011 - journals.lww.com
Objective: To evaluate cell-mediated immune response to Bacillus Calmette–Guérin (BCG)
vaccination in uninfected, HIV-1-exposed infants, comparing it with unexposed children …