The nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis
and post-translational modification in plants, animals, fungi and certain prokaryotes. On the …

Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …

The outer covering of the skin—the epidermis—is subject to sustained environmental
assaults. As a result, many cells acquire potentially oncogenic mutations. Most cells are lost …

We recently reported the cloning of WWOX, a gene that maps to the common fragile site
FRA16D region in chromosome 16q23. 3-24.1. It was observed that the genomic area …

HIT (histidine triad) proteins, named for a motif related to the sequence HϕHϕHϕϕ (ϕ, a
hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases …

We previously reported the construction of a P1-derived artificial chromosome (PAC) contig
encompassing a set of homozygous deletions of chromosome 16q23–24.1 found in primary …

Oral squamous cell carcinoma (OSCC) has a high propensity for local failure, which is
attributed to recurrence at the primary site or the development of second primary tumors …

Cancer cells commonly exhibit various forms of genetic instability, such as changes in
chromosome copy number, translocations and point mutations in particular genes. Although …

Background Cytogenetic alterations underlie the development of squamous cell carcinomas
of the head and neck (SCCHN). Because many of the molecular genetic changes in SCCHN …

In 1979, the first chromosome alteration associated with familial cancer was reported. Five
years later, a fragile site was observed in the same chromosome region. The product of the …