Intermittent hypoxia and neurorehabilitation

EJ Gonzalez-Rothi, KZ Lee, EA Dale… - Journal of applied …, 2015 - journals.physiology.org
In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

The neuroplastic and therapeutic potential of spinal interneurons in the injured spinal cord

LV Zholudeva, L Qiang, V Marchenko… - Trends in …, 2018 - cell.com
The central nervous system is not a static, hard-wired organ. Examples of neuroplasticity,
whether at the level of the synapse, the cell, or within and between circuits, can be found …

Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation

MD Sunshine, AM Cassarà, E Neufeld… - Communications …, 2021 - nature.com
Respiratory insufficiency is a leading cause of death due to drug overdose or neuromuscular
disease. We hypothesized that a stimulation paradigm using temporal interference (TI) could …

Temperature increases by kilohertz frequency spinal cord stimulation

AL Zannou, N Khadka, DQ Truong, T Zhang, R Esteller… - Brain stimulation, 2019 - Elsevier
Introduction Kilohertz frequency spinal cord stimulation (kHz-SCS) deposits significantly
more power in tissue compared to SCS at conventional frequencies, reflecting increased …

Enabling respiratory control after severe chronic tetraplegia: an exploratory case study

P Gad, E Kreydin, H Zhong… - Journal of …, 2020 - journals.physiology.org
Respiratory dysfunction is one of the most debilitating effects of spinal cord injury (SCI)
impacting the quality of life of patients and caregivers. In addition, breathing difficulties …

Respiration following spinal cord injury: evidence for human neuroplasticity

DJ Hoh, LM Mercier, SP Hussey, MA Lane - Respiratory physiology & …, 2013 - Elsevier
Respiratory dysfunction is one of the most devastating consequences of cervical spinal cord
injury (SCI) with impaired breathing being a leading cause of morbidity and mortality in this …

A principle of neuromechanical matching for motor unit recruitment in human movement

AL Hudson, SC Gandevia, JE Butler - Exercise and Sport …, 2019 - journals.lww.com
• The mechanisms are likely to involve premotoneuronal neurons in the spinal cord that
sculpt descending drive to the motoneurons depending on the motor task.• There is …

Respiratory plasticity following spinal cord injury: perspectives from mouse to man

KC Locke, ML Randelman, DJ Hoh… - Neural regeneration …, 2022 - journals.lww.com
The study of respiratory plasticity in animal models spans decades. At the bench,
researchers use an array of techniques aimed at harnessing the power of plasticity within …

Epidural Spinal Cord Stimulation for Spinal Cord Injury in Humans: A Systematic Review

JI Chalif, VS Chavarro, E Mensah, B Johnston… - Journal of Clinical …, 2024 - mdpi.com
(1) Background: Spinal cord injury (SCI) represents a major health challenge, often leading
to significant and permanent sensorimotor and autonomic dysfunctions. This study reviews …

Intraspinal microstimulation for respiratory muscle activation

MD Sunshine, CN Ganji, PJ Reier, DD Fuller… - Experimental …, 2018 - Elsevier
A complex propriospinal network is synaptically coupled to phrenic and intercostal
motoneurons, and this makes it difficult to predict how gray matter intraspinal …