Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules
involved in signal transmission. These receptors play key physiological roles and their …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and
are critically involved in the regulation of different mitogen-activated protein kinase (MAPK) …

Rho GTPases have been implicated in diverse cellular functions and are potential
therapeutic targets. By virtual screening, we have identified a Rho-specific inhibitor, Rhosin …

The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that
transduce diverse intracellular signals leading to the activation of Rho GTPases. The …

G-protein-coupled receptors (GPCRs) are major targets for drug discovery. The regulator of
G-protein signalling (RGS)-protein family has important roles in GPCR signal transduction …

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6
biological capabilities acquired during the development of human tumors. The hallmarks …