Neurotransmitters and neuromodulators have a wide range of key roles throughout the
nervous system. However, their dynamics in both health and disease have been challenging …

Dopamine contributes to cognitive control through well-established effects in both the
striatum and cortex. Although earlier work suggests that dopamine affects cognitive control …

Neurotransmitters play essential roles in regulating neural circuit dynamics both in the
central nervous system as well as at the peripheral, including the gastrointestinal tract …

The noradrenaline (NA) system is one of the brain's major neuromodulatory systems; it
originates in a small midbrain nucleus, the locus coeruleus (LC), and projects widely …

People radically differ in how they cope with uncertainty. Clinical researchers describe a
dispositional characteristic known as “intolerance of uncertainty”, a tendency to find …

Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however,
we have not yet been able to study neuromodulator dynamics as social interaction unfolds …

Many voltammetry methods have been developed to monitor brain extracellular dopamine
levels. Fewer approaches have been successful in detecting serotonin in vivo. No …

In the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode
reward prediction errors that promote learning and guide behavior by causing rapid …

An organism's ability to perceive and respond to changes in its environment is crucial for its
health and survival. Here we reveal how the most well-studied longevity intervention, dietary …

Depression is one of the most common mental diseases, with increasing numbers of
patients globally each year. In addition, approximately 30% of patients with depression are …