The Golgi apparatus and cell polarity: Roles of the cytoskeleton, the Golgi matrix, and Golgi membranes
Membrane trafficking plays a crucial role in cell polarity by directing lipids and proteins to
specific subcellular locations in the cell and sustaining a polarized state. The Golgi …
specific subcellular locations in the cell and sustaining a polarized state. The Golgi …
LRRK2 recruitment, activity, and function in organelles
L Bonet‐Ponce, MR Cookson - The FEBS journal, 2022 - Wiley Online Library
Protein coding mutations in leucine‐rich repeat kinase 2 (LRRK2) cause familial Parkinson's
disease (PD), and noncoding variations around the gene increase the risk of developing …
disease (PD), and noncoding variations around the gene increase the risk of developing …
[HTML][HTML] Endosomal dysfunction induced by directly overactivating Rab5 recapitulates prodromal and neurodegenerative features of Alzheimer's disease
Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer's
disease (AD), is mediated by the aberrant activation of Rab5 triggered by APP-β secretase …
disease (AD), is mediated by the aberrant activation of Rab5 triggered by APP-β secretase …
Endosome-to-TGN trafficking: organelle-vesicle and organelle-organelle interactions
Y Tu, L Zhao, DD Billadeau, D Jia - Frontiers in cell and …, 2020 - frontiersin.org
Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and
lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis …
lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis …
RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes
Arl8b, an Arf-like GTP-binding protein, regulates cargo trafficking and positioning of
lysosomes. However, it is unknown whether Arl8b regulates lysosomal cargo sorting. Here …
lysosomes. However, it is unknown whether Arl8b regulates lysosomal cargo sorting. Here …
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
Lysosomes function not only as degradatory compartments but also as dynamic intracellular
calcium ion stores. The transient receptor potential mucolipin 1 (TRPML1) channel mediates …
calcium ion stores. The transient receptor potential mucolipin 1 (TRPML1) channel mediates …
ARMH3 is an ARL5 effector that promotes PI4KB-catalyzed PI4P synthesis at the trans-Golgi network
ARL5 is a member of the ARF family of small GTPases that is recruited to the trans-Golgi
network (TGN) by another ARF-family member, ARFRP1, in complex with the …
network (TGN) by another ARF-family member, ARFRP1, in complex with the …
Exosomes in pathogenesis, diagnosis, and treatment of pulmonary fibrosis
Y Yang, Y Liu, Y Chai, K Liu, W Hu, K Zhao… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis (PF) is a group of interstitial lung diseases that seriously endanger
human life and health. Despite the current advances in research on the pathogenesis and …
human life and health. Despite the current advances in research on the pathogenesis and …
Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex
The hallmark event of the canonical transforming growth factor β (TGFβ) family signaling is
the assembly of the Smad-complex, consisting of the common Smad, Smad4, and …
the assembly of the Smad-complex, consisting of the common Smad, Smad4, and …
The Ragulator complex: delving its multifunctional impact on metabolism and beyond
K Tsujimoto, H Takamatsu, A Kumanogoh - Inflammation and …, 2023 - Springer
Our understanding of lysosomes has undergone a significant transformation in recent years,
from the view that they are static organelles primarily responsible for the disposal and …
from the view that they are static organelles primarily responsible for the disposal and …