Postmenopausal osteoporosis is a systemic disease characterized by the loss of bone mass
and increased bone fracture risk largely resulting from significantly reduced levels of the …

The term osteoimmunology was coined many years ago to describe the research field that
deals with the cross-regulation between bone cells and the immune system. As a matter of …

Osteoporosis is a major cause of fractures and associated morbidity in the aged population.
The pathogenesis of osteoporosis is multifactorial; whereas traditional pathophysiological …

Osteoporosis (OP) is a disease that weakens bones and has a high morbidity rate
worldwide, which is prevalent among the elderly, particularly, women of postmenopausal …

WNKs are serine/threonine kinases that comprise a unique branch of the kinome. They are
so-named owing to the unusual placement of an essential catalytic lysine. WNKs have now …

Osteoimmunology is the interdiscipline that focuses on the relationship between the skeletal
and immune systems. They are interconnected by shared signal pathways and cytokines …

In the last years, new evidences of the relationship between immune system and bone have
been accumulated both in animal models and in humans affected by bone disease, such as …

One of the major challenges for discovering protein-protein interaction inhibitors is
identifying selective and druggable binding sites at the protein surface. Here, we report an …

Rheumatoid arthritis (RA) is characterized, among other factors, by systemic bone loss,
reaching~ 50% prevalence of osteoporosis in postmenopausal women. This is roughly a …

Osteoporosis is a bone disease characterized by structural deterioration and low bone
mass, leading to fractures and significant health complications. In this review, we summarize …