Asymmetric synthesis with ynamides: unique reaction control, chemical diversity and applications

CC Lynch, A Sripada, C Wolf - Chemical Society Reviews, 2020 - pubs.rsc.org
Ynamides are among the most powerful building blocks in organic synthesis and have
become invaluable starting materials for the construction of multifunctional compounds and …

Recent Advances in Hydrochlorination of Alkenes

W Yaoxin, C Chen, Y Xiaohui - Chinese Journal of Organic …, 2021 - sioc-journal.cn
Organochlorides have been widely used in medicine, pesticides, materials and other fields.
In addition, organochlorides are also important synthetic building blocks. They have …

Selenated NHC-Pd (II) catalyzed Suzuki-Miyaura coupling of ferrocene substituted β-chloro-cinnamaldehydes, acrylonitriles and malononitriles for the synthesis of …

V Tomar, Y Upadhyay, AK Srivastava… - Journal of …, 2021 - Elsevier
Suzuki-Miyaura coupling reaction between ferrocenyl/phenyl derivatives of (2-formyl-1-
chlorovinyl) ferrocene, 3-chloro-3-ferrocenylacrylonitrile and (3-chloro-3 …

Regio-and stereoselective synthesis of 1, 2-dihaloalkenes using in-situ-generated ICl, IBr, BrCl, I2, and Br2

X Zeng, S Liu, Y Yang, Y Yang, GB Hammond, B Xu - Chem, 2020 - cell.com
We describe a catalyst-free 1, 2-trans-dihalogenation of alkynes with an unprecedented
substrate scope and exclusive regio-and stereoselectivity. This versatile dihalogenation …

Stereoselective Alkyne Hydrohalogenation by Trapping of Transfer Hydrogenation Intermediates

M Das, T Kaicharla, JF Teichert - Organic letters, 2018 - ACS Publications
A catalytically generated vinylcopper complex, the reactive intermediate of a copper (I)-
catalyzed alkyne transfer hydrogenation, can be trapped by commercially available halogen …

Quaternary Ammonium Salts: Catalysts for Hydrosilylation of Alkynes with Hydrosilanes

H Andoh, K Nakamura, Y Nakazawa… - Advanced Synthesis …, 2023 - Wiley Online Library
Mixing i‐PrI and DABCO in solvent EtCN gave two quaternary ammonium salts (QASs)
quantitatively, one of which is monocationic (QAS‐1) and the other is dicationic (QAS‐2) …

Regio- and Stereocontrolled Hydrohalogenation of Ynamides with N-Halosuccinimides (NXS) as the Halogen Source: Synthesis of (E)-α-Haloenamides

SS Pati, A Mishra, JP Das - The Journal of Organic Chemistry, 2024 - ACS Publications
Presented herein is a facile stereoselective construction of synthetically versatile chiral and
achiral (E)-α-haloenamides under mild conditions utilizing N-halosuccinimides and …

Diorganyl diselenides and iron (III) chloride drive the regio-and stereoselectivity in the selenation of ynamides

TAC Goulart, DF Back, S Moura E. Silva… - The Journal of Organic …, 2020 - ACS Publications
We report here our results on the application of ynamides as substrates in the reactions with
diorganyl dichalcogenides and iron (III) chloride to give selectively three different types of …

Stereoselective Synthesis of Pyrido- and Pyrrolo[1,2-c][1,3]oxazin-1-ones via a Nucleophilic Addition–Cyclization Process of N,O-Acetal with Ynamides

P Han, ZY Mao, CM Si, Z Zhou, BG Wei… - The Journal of Organic …, 2018 - ACS Publications
An efficient asymmetric approach to access functionalized pyrido-and pyrrolo [1, 2-c][1, 3]
oxazin-1-ones has been developed through a nucleophilic addition–cyclization process of …

A 5+ 1 protic acid assisted aza-pummerer approach for synthesis of 4-chloropiperidines from homoallylic amines

R Ebule, S Mudshinge, MH Nantz… - The Journal of …, 2019 - ACS Publications
We report that HCl· DMPU induces the formation of (thiomethyl) methyl carbenium ion from
DMSO under mild conditions. Homoallylic amines react with this electrophile to generate 4 …