Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Fungal diseases represent an important paradigm in immunology, as they can result from
either a lack of recognition by the immune system or overactivation of the inflammatory …

Abstract CD4+ T helper (Th) cells exist in a variety of epigenetic states that determine their
function, phenotype, and capacity for persistence. These polarization states include Th1 …

The C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study,
the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading …

Since their identification in 2005, T helper (Th) 17 cells have been proposed to play
important roles in several human diseases, including various autoimmune conditions …

Somatic cell nuclear transfer (SCNT), the technique commonly known as cloning, permits
transformation of a somatic cell into an undifferentiated zygote with the potential to develop …

Curcumin has a therapeutic effect on ulcerative colitis, but the underlying mechanism has
yet to be elucidated. The aim of the present study was to clarify the possible mechanisms …

An improved understanding of the pathogenesis of Aspergillus infections has facilitated the
identification of host biomarkers that, if validated in well-designed prospective studies, could …

Multiple candidate gene-association studies of non-HLA single-nucleotide polymorphisms
(SNPs) and outcomes after blood or marrow transplant (BMT) have been conducted. We …

Background. Acute myeloid leukemia (AML) shows a high degree of heterogeneity owing to
a variety of mutations and the mechanisms of leukemogenesis. This heterogeneity is often …