New developments in RiPP discovery, enzymology and engineering
M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
Thiopeptides: antibiotics with unique chemical structures and diverse biological activities
DCK Chan, LL Burrows - The Journal of Antibiotics, 2021 - nature.com
Thiopeptides are a class of natural product antibiotics with diverse structures and functions.
Their complex structures and biosynthesis have intrigued researchers since their discovery …
Their complex structures and biosynthesis have intrigued researchers since their discovery …
Radical SAM enzymes in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs)
A Benjdia, C Balty, O Berteau - Frontiers in chemistry, 2017 - frontiersin.org
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and
diverse family of natural products. They possess interesting biological properties such as …
diverse family of natural products. They possess interesting biological properties such as …
Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis
Ribosomally synthesized and post-translationally modified peptides (RiPPs) display a
diverse range of structures and continue to expand as a natural product class. Accordingly …
diverse range of structures and continue to expand as a natural product class. Accordingly …
Revisiting the mechanism of the anaerobic coproporphyrinogen III oxidase HemN
HemN is a radical S‐adenosyl‐l‐methionine (SAM) enzyme that catalyzes the oxidative
decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX, an …
decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX, an …
Enzymatic macrocyclization of ribosomally synthesized and posttranslational modified peptides via C–S and C–C bond formation
Covering: 2000 to 2020 Ribosomally synthesized and posttranslational modified peptides
(RiPPs) are a rapidly growing class of bioactive natural products. Many members of RiPPs …
(RiPPs) are a rapidly growing class of bioactive natural products. Many members of RiPPs …
Functional diversity of HemN-like proteins
J Cheng, WQ Liu, X Zhu, Q Zhang - ACS bio & med Chem Au, 2022 - ACS Publications
HemN is a radical S-adenosylmethionine (SAM) enzyme that catalyzes the anaerobic
oxidative decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX, a key …
oxidative decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX, a key …
Expanding the chemistry of the class C radical SAM methyltransferase NosN by using an Allyl analogue of SAM
The radical S‐adenosylmethionine (SAM) superfamily enzymes cleave SAM reductively to
generate a highly reactive 5′‐deoxyadenosyl (dAdo) radical, which initiates remarkably …
generate a highly reactive 5′‐deoxyadenosyl (dAdo) radical, which initiates remarkably …
Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide …
B Wang, JW LaMattina, SL Marshall… - Journal of the American …, 2019 - ACS Publications
Nosiheptide is a ribosomally synthesized and post-translationally modified thiopeptide
natural product that possesses antibacterial, anticancer, and immunosuppressive properties …
natural product that possesses antibacterial, anticancer, and immunosuppressive properties …
Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions
WB Jin, S Wu, YF Xu, H Yuan, GL Tang - Natural Product Reports, 2020 - pubs.rsc.org
Covering: 2012 to 2019 HemN-like radical S-adenosyl-L-methionine (SAM) enzymes have
been recently disclosed to catalyze diverse chemically challenging reactions from primary to …
been recently disclosed to catalyze diverse chemically challenging reactions from primary to …