Class II terpene cyclases: structures, mechanisms, and engineering

X Pan, JD Rudolf, LB Dong - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

Biosynthesis and assembly logic of fungal hybrid terpenoid natural products

GY Yuan, JM Zhang, YQ Xu, Y Zou - ChemBioChem, 2024 - Wiley Online Library
In recent decades, fungi have emerged as significant sources of diverse hybrid terpenoid
natural products, and their biosynthetic pathways are increasingly unveiled. This review …

Dissection of the catalytic mechanisms of transmembrane terpene cyclases involved in fungal meroterpenoid biosynthesis

J Tang, Y Matsuda - Angewandte Chemie, 2023 - Wiley Online Library
Pyr4‐family terpene cyclases are noncanonical transmembrane terpene cyclases involved
in the biosynthesis of microbial meroterpenoids and catalyze diverse cyclization reactions …

Anti-diabetic and anti-inflammatory indole diterpenes from the marine-derived fungus Penicillium sp. ZYX-Z-143

LT Dai, L Yang, JC Guo, QY Ma, QY Xie, L Jiang… - Bioorganic …, 2024 - Elsevier
Seven new indole-diterpenoids, penpaxilloids A–E (1–5), 7-methoxypaxilline-13-ene (6),
and 10-hydroxy-paspaline (7), along with 20 known ones (8–27), were isolated from the …

Functional analysis of transmembrane terpene cyclases involved in fungal meroterpenoid biosynthesis

J Tang, Y Matsuda - Terpene Synthases, 2024 - books.google.com
1. Introduction 2. Artificial-intelligence-based prediction of enzyme structures and
mechanisms 2.1 Procedure for the generation of a model structure using ColabFold v1. 5.2 …