Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

Rheumatoid arthritis (RA) is an autoimmune disease affecting synovial joints where different
CD4+ T cell subsets may contribute to pathology. Here, we perform single cell sequencing …

CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term in
vitro cultures but have in more recent years become accepted and reported in the literature …

Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …

The predisposition of individuals to several common autoimmune diseases, such as
rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, is genetically …

Epstein-Barr virus (EBV)–associated nasopharyngeal carcinoma (NPC) is the third most
frequent virus-associated human malignancy. How this tumor escapes immune recognition …

Virus-specific CD4 T cells are endowed with multiple functions, such as cytokine production,
CD40 ligand (CD40L) expression (associated with the costimulation of CD8 and B cells) …

Posttransplantation lymphoproliferative disease (PTLD) associated with Epstein-Barr virus
(EBV) is a life-threatening complication after allogeneic hematopoietic stem cell …

CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in
humans, mice, and other species in response to many diverse pathogens. Since CD4 …