Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

PR Angelova, N Esteras… - Medicinal Research …, 2021 - Wiley Online Library
The world's population aging progression renders age‐related neurodegenerative diseases
to be one of the biggest unsolved problems of modern society. Despite the progress in …

Tea and its phytochemicals: Hidden health benefits & modulation of signaling cascade by phytochemicals

S Bag, A Mondal, A Majumder, A Banik - Food Chemistry, 2022 - Elsevier
Tea, one of the most widely consumed beverages, is prepared from the leaves of the
Camellia sinensis. The promising health recompenses of tea have been linked to its different …

Herbal medicine: biomolecular and clinical aspects

IFF Benzie, S Wachtel-Galor - 2011 - books.google.com
Responding to the increased popularity of herbal medicines and other forms of
complementary or alternative medicine world-wide, this reference reviews and evaluates …

Plant‐derived anti‐inflammatory compounds: Hopes and disappointments regarding the translation of preclinical knowledge into clinical progress

R Fürst, I Zündorf - Mediators of inflammation, 2014 - Wiley Online Library
Many diseases have been described to be associated with inflammatory processes. The
currently available anti‐inflammatory drug therapy is often not successful or causes …

Antibacterial green tea catechins from a molecular perspective: Mechanisms of action and structure–activity relationships

A Renzetti, JW Betts, K Fukumoto, RN Rutherford - Food & function, 2020 - pubs.rsc.org
This review summarizes the mechanisms of antibacterial action of green tea catechins,
discussing the structure–activity relationship (SAR) studies for each mechanism. The …

Secretion of tau via an unconventional non-vesicular mechanism

M Merezhko, CA Brunello, X Yan, H Vihinen, E Jokitalo… - Cell reports, 2018 - cell.com
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …

Compounds triggering ER stress exert anti-melanoma effects and overcome BRAF inhibitor resistance

M Cerezo, A Lehraiki, A Millet, F Rouaud, M Plaisant… - Cancer cell, 2016 - cell.com
We have discovered and developed a series of molecules (thiazole benzenesulfonamides).
HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma …

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

Y Ogawa, Y Nonaka, T Goto, E Ohnishi… - Nature …, 2010 - nature.com
Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) is a
serine/threonine kinase essential for brain development and function, and its excessive …

Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

KJ Gardiner - Drug design, development and therapy, 2014 - Taylor & Francis
Down syndrome (DS), also known as trisomy 21, is the most common genetic cause of
intellectual disability (ID). Although ID can be mild, the average intelligence quotient is in the …

The role of natural polyphenols in cell signaling and cytoprotection against cancer development

H Lewandowska, M Kalinowska… - The Journal of nutritional …, 2016 - Elsevier
The cytoprotective and anticancer action of dietary in-taken natural polyphenols has for long
been attributed only to their direct radical scavenging activities. Currently it is well supported …