Due to the increasing bacterial resistance to conventional antibiotics, developing safe and
effective approaches to combat infections caused by bacteria and biofilms has become an …

Nearly 30 hereditary disorders in humans result from an increase in the number of copies of
simple repeats in genomic DNA. These DNA repeats seem to be predisposed to such …

Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked G–G–G–G
tetrads in monovalent cation-containing solution. The length and number of individual G …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

We show that intracellular transcription of G-rich regions produces novel DNA structures,
visible by electron microscopy as large (150–500 bp) loops. These G-loops are formed …

Alterations in genome sequence and structure contribute to somatic disease, affect the
fitness of subsequent generations and drive evolutionary processes. The crucial roles of …

The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruplex
structure, which has been shown to directly inhibit telomerase activity. The reactivation of …

▪ Abstract One strand of cellular DNA is generated as RNA-initiated discontinuous segments
called Okazaki fragments that later are joined. The RNA terminated region is displaced into …

The role of nonlinear DNA in replication, recombination, and transcription has become
evident in recent years. Although several studies have predicted and characterized …