G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They
are key players in the majority of biologic functions including vision, olfaction, chemotaxis …

Within over 800 members of G-protein-coupled receptors, there are numerous orphan
receptors whose endogenous ligands are largely unknown, providing many opportunities for …

GPCRs regulate multiple intracellular signaling cascades. Biasedly activating one signaling
pathway over the others provides additional clinical utility to optimize GPCR-based …

We unveil the intimate relationship between protein dynamics and allostery by following the
trajectories of model proteins in their conformational and sequence spaces. Starting from a …

Allosteric regulation is a powerful mechanism for controlling the efficiency of enzymes.
Deciphering the evolutionary mechanisms by which allosteric properties have been …

Biomolecular nanotechnology has helped emulate basic robotic capabilities such as defined
motion, sensing, and actuation in synthetic nanoscale systems. DNA origami is an attractive …

The molecular basis of receptor bias in G protein-coupled receptors (GPCRs) caused by
mutations that preferentially activate specific intracellular transducers over others remains …

Polyphenol oxidase (PPO)-mediated browning can have adverse effects on foods' quality
during processing. Therefore, it's important to find natural and efficient PPO-inhibitors. This …

G-protein coupled receptors (GPCRs) are eukaryotic integral membrane proteins that
regulate signal transduction cascade pathways implicated in a variety of human diseases …

With the advent of AI-powered structure prediction, the scientific community is inching closer
to solving protein folding. An unresolved enigma, however, is to accurately, reliably, and …