The role of tumor microenvironment in multiple myeloma development and progression

A Garcia-Ortiz, Y Rodríguez-García, J Encinas… - Cancers, 2021 - mdpi.com
Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …

Targeting B cell maturation antigen (BCMA) in multiple myeloma: potential uses of BCMA-based immunotherapy

SF Cho, KC Anderson, YT Tai - Frontiers in immunology, 2018 - frontiersin.org
The approval of the first two monoclonal antibodies targeting CD38 (daratumumab) and
SLAMF7 (elotuzumab) in late 2015 for treating relapsed and refractory multiple myeloma …

Immunotherapy of multiple myeloma

SA Minnie, GR Hill - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
Multiple myeloma (MM), a bone marrow–resident hematological malignancy of plasma cells,
has remained largely incurable despite dramatic improvements in patient outcomes in the …

Recent advances in cell membrane‐derived biomimetic nanotechnology for cancer immunotherapy

F Raza, H Zafar, S Zhang, Z Kamal, J Su… - Advanced …, 2021 - Wiley Online Library
Immunotherapy will significantly impact the standard of care in cancer treatment. Recent
advances in nanotechnology can improve the efficacy of cancer immunotherapy. However …

How to train your T cells: overcoming immune dysfunction in multiple myeloma

AD Cohen, N Raje, JA Fowler, K Mezzi, EC Scott… - Clinical Cancer …, 2020 - AACR
The progression of multiple myeloma, a hematologic malignancy characterized by
unregulated plasma cell growth, is associated with increasing innate and adaptive immune …

Bispecific antibodies for multiple myeloma: a review of targets, drugs, clinical trials, and future directions

C Caraccio, S Krishna, DJ Phillips… - Frontiers in …, 2020 - frontiersin.org
Multiple myeloma (MM) is a plasma cell malignancy and the second most common
hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual incidence …

Bispecific antibodies in the treatment of multiple myeloma

AJ Devasia, A Chari, G Lancman - Blood Cancer Journal, 2024 - nature.com
The treatment paradigm in myeloma is constantly changing. Upfront use of monoclonal
antibodies like daratumumab along with proteasome inhibitors (PI) s, and immune …

Immune-based therapies in the management of multiple myeloma

S Zanwar, B Nandakumar, S Kumar - Blood cancer journal, 2020 - nature.com
Multiple myeloma (MM) is a clonal plasma cell malignancy affecting a predominantly elderly
population. The continued development of newer therapies with novel mechanisms of action …

Nano-immunotherapy: Overcoming tumour immune evasion

ML Guevara, F Persano, S Persano - Seminars in Cancer Biology, 2021 - Elsevier
Immunotherapy is emerging as a groundbreaking cancer treatment, offering the
unprecedented opportunity to effectively treat and in several cases, even cure previously …

Regulatory B cell-myeloma cell interaction confers immunosuppression and promotes their survival in the bone marrow milieu

L Zhang, YT Tai, M Ho, L Xing, D Chauhan… - Blood cancer …, 2017 - nature.com
Multiple myeloma (MM), a terminally differentiated B-cell malignancy, is characterized by
excess bone marrow (BM) plasma cells and immunosuppression. At present, the role of B …