Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Actin filaments form contractile and protrusive structures that play central roles in many
processes such as cell migration, morphogenesis, endocytosis, and cytokinesis. During …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
presence of intracellular neurofibrillary tangles (NFTs) containing hyperphosphorylated tau …

Cell locomotion and endocytosis are powered by the rapid polymerization and turnover of
branched actin filament networks nucleated by Arp2/3 complex [1]. Although a large number …

Parkinson's disease (PD) is a progressive movement disorder characterized by
neuroinflammation and dopaminergic neurodegeneration in the brain. 1-methyl-4 …

Sponges were first grouped to the animal-plants or plant-animals then to the Zoophyta or
Mesozoa and finally to the Parazoa. Only after the application of molecular biological …

Inflammatory mediators released from activated microglia, astrocytes, neurons, and mast
cells mediate neuroinflammation. Parkinson's disease (PD) is characterized by inflammation …

Neuroinflammation plays an active role in the pathogenesis of several neurodegenerative
diseases, including Parkinson's disease (PD). Earlier studies from this laboratory showed …

The glia maturation factor (GMF), which was discovered in our laboratory, is a highly
conserved protein predominantly localized in astrocytes. GMF is an intracellular regulator of …

Epigenetic alterations are a fundamental pathological hallmark of Alzheimer's disease (AD).
Herein, we show the upregulation of G9a and H3K9me2 in the brains of AD patients …