The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by
perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in …

The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …

The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

The CNS is endowed with an elaborated response repertoire termed'neuroinflammation',
which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of …

Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …

In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …

Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …