Lung cancer organoids: the rough path to personalized medicine

R Rossi, ML De Angelis, E Xhelili, G Sette, A Eramo… - Cancers, 2022 - mdpi.com
Simple Summary Lung cancer is very difficult to cure, especially when it has spread to other
parts of the body. One of the main reasons that delay the identification of effective therapies …

Biosensor integrated brain-on-a-chip platforms: progress and prospects in clinical translation

B Cecen, E Saygili, I Zare, O Nejati, D Khorsandi… - Biosensors and …, 2023 - Elsevier
Because of the brain's complexity, developing effective treatments for neurological disorders
is a formidable challenge. Research efforts to this end are advancing as in vitro systems …

Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid maturation and does not impede growth

X Tang, Z Wang, D Khutsishvili, Y Cheng, J Wang… - Cell Systems, 2023 - cell.com
Although biochemical regulation has been extensively studied in organoid modeling
protocols, the role of mechanoregulation in directing stem cell fate and organoid …

Transparent Intracellular Sensing Platform with Si Needles for Simultaneous Live Imaging

W Park, EM Kim, Y Jeon, J Lee, J Yi, J Jeong, B Kim… - ACS …, 2023 - ACS Publications
Vertically ordered Si needles are of particular interest for long-term intracellular recording
owing to their capacity to infiltrate living cells with negligible damage and minimal toxicity …

Recent frontiers in biofabrication for respiratory tissue engineering

A Zimmerling, NA Dahlan, Y Zhou, X Chen - Bioprinting, 2024 - Elsevier
Respiratory tissue engineering offers a robust framework for studying cell-cell and host-
pathogen interactions in a tissue-like environment and offers a platform for studying lung …

Replacing animal testing with stem cell-organoids: advantages and limitations

G Park, YA Rim, Y Sohn, Y Nam, JH Ju - Stem Cell Reviews and Reports, 2024 - Springer
Various groups including animal protection organizations, medical organizations, research
centers, and even federal agencies such as the US Food and Drug Administration, are …

[HTML][HTML] Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry

P Stüve, B Nerb, S Harrer, M Wuttke, M Feuerer… - Frontiers in …, 2024 - frontiersin.org
Organoids are three-dimensional (3D) structures that can be derived from stem cells or adult
tissue progenitor cells and exhibit an extraordinary ability to autonomously organize and …

Human brain organoid: A versatile tool for modeling neurodegeneration diseases and for drug screening

C Ma, H Seong, X Li, X Yu, S Xu, Y Li - Stem Cells International, 2022 - Wiley Online Library
Clinical trials serve as the fundamental prerequisite for clinical therapy of human disease,
which is primarily based on biomedical studies in animal models. Undoubtedly, animal …

High-resolution spatiotemporal analysis of single serotonergic axons in an in vitro system

M Hingorani, AML Viviani, JE Sanfilippo… - Frontiers in …, 2022 - frontiersin.org
Vertebrate brains have a dual structure, composed of (i) axons that can be well-captured
with graph-theoretical methods and (ii) axons that form a dense matrix in which neurons with …

Engineering Biomimetic Microenvironment for Organoid

S Chen, L Wang, L Yang, AS Rana… - Macromolecular …, 2023 - Wiley Online Library
Organoid is an emerging frontier technology in the field of life science, in which pluripotent
stem cells or tissue‐derived differentiated/progenitor cells form 3D structures according to …