Type 1 diabetes mellitus (T1DM) is an autoimmune disease arising through a complex
interaction of both genetic and immunologic factors. Similar to the majority of autoimmune …

Rapid advances in molecular biological techniques have made it possible to study disease
pathogenesis at a genomic level. T cell receptor (TCR) gene rearrangement is an important …

Type I (insulin-dependent) diabetes mellitus is a heterogeneous disease with major
subdivisions termed Type 1A (immune-mediated) and Type 1B. Immune-mediated diabetes …

Genetic studies have identified> 60 loci associated with the risk of developing type 1
diabetes (T1D). The vast majority of these are identified by genome‐wide association …

Type 1A diabetes is a chronic autoimmune disease usually preceded by a long prodrome
during which autoantibodies to islet autoantigens are present. These antibodies are directed …

Type 1 diabetes mellitus (T1D) is an autoimmune disease encompassing the T-cell-
mediated destruction of pancreatic β cells and the production of autoantibodies against islet …

Type 1 diabetes is a T cell mediated autoimmune disease, characterised by the selective
destruction of pancreatic β cells, and susceptibility is determined by a combination of genetic …

The objective of this study was to determine the extent to which different screening strategies
could identify a population of nondiabetic relatives of a proband with type 1 diabetes who …

Type 1 diabetes mellitus (T1D) remains the most intensively studied, and thus the best
paradigm, of MHC-associated diseases. Accumulating evidence suggests that MHC …

The HLA-DRB1* 15: 01-DQA1* 01: 02-DQB1* 06: 02 haplotype is linked to protection from
the development of type 1 diabetes (T1D). However, it is not known at which stages in the …