Raynaud’s Phenomenon | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

There are two major clinical subsets of scleroderma:(i) systemic sclerosis (SSc) is a complex
systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive …

Raynaud's phenomenon is a common clinical disorder for which patients frequently seek the
expertise and care of dermatologists. It is manifested by recurrent vasospasm of the fingers …

Nitric oxide has emerged as one of the most important neurotransmitters mediating internal
anal sphincter relaxation. The effect of glyceryl trinitrate, a nitric oxide donor, on anal tone …

We review data from controlled trials and randomised controlled trials to examine the
hypothesis for the pathogenesis of systemic sclerosis. Strategies used to treat the vascular …

Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable
mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and …

PURPOSE: Nitric oxide is an important neurotransmitter mediating internal anal sphincter
relaxation. Patients suffering from fissure-in-ano were treated with topical nitroglycerine. The …

Objective Raynaud's phenomenon (RP) affects 3–9% of the general population and> 90% of
patients with systemic sclerosis. Nitrates are often prescribed for the treatment of RP, but …

A randomized, double-blind, placebo controlled, cross-over study was conducted to
determine the clinical efficacy of and patient tolerance to sustained-release glyceryl trinitrate …

Raynaud's phenomenon is a common condition characterized by vasospasm of the digital
arteries and resulting cyanosis and redness. It often does not require pharmacologic …