Mathematical modeling of circadian rhythms
A Asgari‐Targhi, EB Klerman - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
Circadian rhythms are endogenous~ 24‐hr oscillations usually entrained to daily
environmental cycles of light/dark. Many biological processes and physiological functions …
environmental cycles of light/dark. Many biological processes and physiological functions …
Adolescent sleep patterns in humans and laboratory animals
MH Hagenauer, TM Lee - Hormones and behavior, 2013 - Elsevier
This article is part of a Special Issue “Puberty and Adolescence”. One of the defining
characteristics of adolescence in humans is a large shift in the timing and structure of sleep …
characteristics of adolescence in humans is a large shift in the timing and structure of sleep …
Physiologically-based modeling of sleep–wake regulatory networks
Mathematical modeling has played a significant role in building our understanding of sleep–
wake and circadian behavior. Over the past 40 years, phenomenological models, including …
wake and circadian behavior. Over the past 40 years, phenomenological models, including …
The interaction effect of sleep deprivation and cannabinoid type 1 receptor in the CA1 hippocampal region on passive avoidance memory, depressive-like behavior …
Increasing evidence shows the interaction effect of cannabinoids and sleep on cognitive
functions. In the present study, we aimed to investigate the interaction effect of cannabinoids …
functions. In the present study, we aimed to investigate the interaction effect of cannabinoids …
A mathematical model towards understanding the mechanism of neuronal regulation of wake-NREMS-REMS states
In this study we have constructed a mathematical model of a recently proposed functional
model known to be responsible for inducing waking, NREMS and REMS. Simulation studies …
model known to be responsible for inducing waking, NREMS and REMS. Simulation studies …
Mammalian rest/activity patterns explained by physiologically based modeling
AJK Phillips, BD Fulcher, PA Robinson… - PLoS Computational …, 2013 - journals.plos.org
Circadian rhythms are fundamental to life. In mammals, these rhythms are generated by
pacemaker neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is …
pacemaker neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is …
Arousal state feedback as a potential physiological generator of the ultradian REM/NREM sleep cycle
AJK Phillips, PA Robinson, EB Klerman - Journal of theoretical biology, 2013 - Elsevier
Human sleep episodes are characterized by an approximately 90-min ultradian oscillation
between rapid eye movement (REM) and non-REM (NREM) sleep stages. The source of this …
between rapid eye movement (REM) and non-REM (NREM) sleep stages. The source of this …
NREM–REM alternation complicates transitions from napping to non-napping behavior in a three-state model of sleep–wake regulation
C Athanasouli, K Kalmbach, V Booth… - Mathematical …, 2023 - Elsevier
The temporal structure of human sleep changes across development as it consolidates from
the polyphasic sleep of infants to the single nighttime sleep episode typical in adults …
the polyphasic sleep of infants to the single nighttime sleep episode typical in adults …
Modeling the effect of sleep regulation on a neural mass model
In mammals, sleep is categorized by two main sleep stages, rapid eye movement (REM) and
non-REM (NREM) sleep that are known to fulfill different functional roles, the most notable …
non-REM (NREM) sleep that are known to fulfill different functional roles, the most notable …
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage
The devastating chronic central post stroke pain is associated with variety of comorbidities.
Disrupted sleep is a severe comorbidity, causing an increase in the suicide rate, due to …
Disrupted sleep is a severe comorbidity, causing an increase in the suicide rate, due to …