Covering: 2000 to 2015 Despite a pervasive decline in natural product research at many
pharmaceutical companies over the last two decades, natural products have undeniably …

During the past two decades, the technological progress of whole-genome sequencing
(WGS) had changed the fields of Environmental Microbiology and Biotechnology, and …

The overuse of broad-spectrum antibiotics rapidly selects for dangerous multi-drug resistant
bacterial pathogens. The landscape of antibiotic drug discovery is adapting to this wave of …

The doom and gloom of antibiotic resistance dominates public perception of this drug class.
Many believe the world has entered the post-antibiotic era. Classic and modern approaches …

Mycobacterium tuberculosis relies on its own ability to biosynthesize coenzyme A to meet
the needs of the myriad enzymatic reactions that depend on this cofactor for activity. As such …

Essential genes encode the processes that are necessary for life. Until recently, commonly
applied binary classifications left no space between essential and non-essential genes. In …

The Apicomplexa phylum comprises thousands of distinct intracellular parasite species,
including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are …

The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl
carrier in all organisms, have long been regarded as excellent targets for the development of …

Despite decades of dedicated research, there remains a dire need for new drugs against
tuberculosis (TB). Current therapies are generations old and problematic. Resistance to …

Highlights•Bioactivity-based discovery has yielded an array of new antibacterial compounds
and targets.•Exploiting phenotypic determinants and intraspecies and interspecies …