Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair
response disorder when organs undergo continuous damage, ultimately leading to scar …

Hepatic fibrosis occurs during chronic hepatic injury and is involved in hepatic stellate cells
(HSCs) activated by several types of immune cells. Among the immune cells, hepatic …

Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells
(HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for …

The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP)
pathways intersect at multiple signaling hubs and cooperatively or counteractively …

Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …

Hepatic fibrosis represents as a dynamic pathological process characterized by the net
accumulation of extracellular matrix in the progression of various chronic liver diseases …

The incidence and mortality of hepatitis B virus (HBV)-associated hepatocellular carcinoma
(HBV-HCC) is an intractable public health problem in developing countries that is …

Fibrosis is the excessive deposition of extracellular matrix components, which results in
disruption of tissue architecture and loss of organ function. Fibrosis leads to high morbidity …

Arsenicosis induced by chronic exposure to arsenic is recognized as one of the main
damaging effects on public health. Exposure to arsenic can cause hepatic fibrosis, but the …