Modeling Alzheimer's disease with iPSC-derived brain cells
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
Induced pluripotent stem cell technology: a decade of progress
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …
enormous progress has been made in stem cell biology and regenerative medicine. Human …
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients
Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …
[HTML][HTML] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders
H Okano, S Morimoto - Cell Stem Cell, 2022 - cell.com
It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …
technology in 2007, and the scope of its application has been expanding. In addition to the …
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
D Paquet, D Kwart, A Chen, A Sproul, S Jacob, S Teo… - Nature, 2016 - nature.com
The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many
organisms and holds promise as a tool to generate models of human diseases, for example …
organisms and holds promise as a tool to generate models of human diseases, for example …
Induced pluripotent stem cells and their use in human models of disease and development
P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies,
only to fail in human trials, suggesting a pressing need to study AD in human model …
only to fail in human trials, suggesting a pressing need to study AD in human model …
Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases
Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …
research as we are still struggling to understand the interface between the aging process …
PSEN1 mutant iPSC-derived model reveals severe astrocyte pathology in Alzheimer's disease
M Oksanen, AJ Petersen, N Naumenko, K Puttonen… - Stem cell reports, 2017 - cell.com
Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause
of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there …
of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there …
A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP β-CTFs, not Aβ
D Kwart, A Gregg, C Scheckel, EA Murphy, D Paquet… - Neuron, 2019 - cell.com
Familial Alzheimer's disease (fAD) results from mutations in the amyloid precursor protein
(APP) and presenilin (PSEN1 and PSEN2) genes. Here we leveraged recent advances in …
(APP) and presenilin (PSEN1 and PSEN2) genes. Here we leveraged recent advances in …