A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2
G Padroni, M Bikaki, M Novakovic… - Nucleic Acids …, 2023 - academic.oup.com
The pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new
insights into the biology of betacoronaviruses to inform drug screening and development …
insights into the biology of betacoronaviruses to inform drug screening and development …
Deletion of the s2m RNA structure in the avian coronavirus infectious bronchitis virus and human astrovirus results in sequence insertions
Coronaviruses infect a wide variety of host species, resulting in a range of diseases in both
humans and animals. The coronavirus genome consists of a large positive-sense single …
humans and animals. The coronavirus genome consists of a large positive-sense single …
Genetic diversity and evolutionary dynamics of the Omicron variant of SARS-CoV-2 in Morocco
Among the numerous variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) that have been reported worldwide, the emergence of the Omicron variant has …
CoV-2) that have been reported worldwide, the emergence of the Omicron variant has …
The highly conserved stem-loop II motif is dispensable for SARS-CoV-2
The stem-loop II motif (s2m) is an RNA structural element that is found in the 3′
untranslated region (UTR) of many RNA viruses, including severe acute respiratory …
untranslated region (UTR) of many RNA viruses, including severe acute respiratory …
Effect of the SARS-CoV-2 Delta-associated G15U mutation on the s2m element dimerization and its interactions with miR-1307-3p
The s2m, a highly conserved 41-nt hairpin structure in the SARS-CoV-2 genome, serves as
an attractive therapeutic target that may have important roles in the virus life cycle or …
an attractive therapeutic target that may have important roles in the virus life cycle or …
Structural, dynamical, and entropic differences between SARS-CoV and SARS-CoV-2 s2m elements using molecular dynamics simulations
AH Kensinger, JA Makowski… - ACS Physical …, 2022 - ACS Publications
The functional role of the highly conserved stem-loop II motif (s2m) in SARS-CoV and SARS-
CoV-2 in the viral lifecycle remains enigmatic and an intense area of research. Structure and …
CoV-2 in the viral lifecycle remains enigmatic and an intense area of research. Structure and …
NMR characterization and ligand binding site of the stem–loop 2 motif from the Delta variant of SARS-CoV-2
T Matzel, MW Martin, A Herr, A Wacker, C Richter… - RNA, 2024 - rnajournal.cshlp.org
The stem–loop 2 motif (s2m) in SARS-CoV-2 (SCoV-2) is located in the 3′-UTR. Although
s2m has been reported to display characteristics of a mobile genomic element that might …
s2m has been reported to display characteristics of a mobile genomic element that might …
Delta SARS-CoV-2 s2m structure, dynamics, and entropy: consequences of the G15U mutation
JA Makowski, AH Kensinger… - ACS Physical …, 2023 - ACS Publications
Bioinformatic analysis of the Delta SARS-CoV-2 genome reveals a single nucleotide
mutation (G15U) in the stem-loop II motif (s2m) relative to ancestral SARS-CoV-2. Despite …
mutation (G15U) in the stem-loop II motif (s2m) relative to ancestral SARS-CoV-2. Despite …
Buffer choice and pH strongly influence phase separation of SARS-CoV-2 nucleocapsid with RNA
The SARS-CoV-2 nucleocapsid (N) protein is crucial for virus replication and genome
packaging. N protein forms biomolecular condensates both in vitro and in vivo in a process …
packaging. N protein forms biomolecular condensates both in vitro and in vivo in a process …
Interactions of the SARS-CoV-2 Viral Genome 3'-Untranslated Region with Viral and Host RNAs
CJ Frye - 2024 - search.proquest.com
This dissertation focuses on the characterization of RNA-RNA interactions within the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and with host microRNAs …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and with host microRNAs …