Genotypic testing for human immunodeficiency virus type 1 drug resistance

RW Shafer - Clinical microbiology reviews, 2002 - Am Soc Microbiol
There are 16 approved human immunodeficiency virus type 1 (HIV-1) drugs belonging to
three mechanistic classes: protease inhibitors, nucleoside and nucleotide reverse …

Antifungal resistance trends towards the year 2000: implications for therapy and new approaches

BD Alexander, JR Perfect - Drugs, 1997 - Springer
Medical advances have led to increased numbers of immunocompromised patients living
longer. Coinciding with this increase in the immunocompromised patient population is an …

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

JM Coffin - Science, 1995 - science.org
Several recent reports indicate that the long, clinically latent phase that characterizes human
immunodeficiency virus (HIV) infection of humans is not a period of viral inactivity, but an …

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

DD Richman, T Wrin, SJ Little… - Proceedings of the …, 2003 - National Acad Sciences
A recombinant virus assay was used to characterize in detail neutralizing antibody
responses directed at circulating autologous HIV in plasma. Examining serial plasma …

A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy

JD Baxter, DL Mayers, DN Wentworth, JD Neaton… - Aids, 2000 - journals.lww.com
A randomized study of antiretroviral management based on pla... : AIDS A randomized study of
antiretroviral management based on plasma genotypic antiretroviral resistance testing in …

Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)

R Schuurman, M Nijhuis… - Journal of Infectious …, 1995 - academic.oup.com
The effect of the appearance of drug-resistant human immunodeficiency virus type 1 (HIV-1)
on viral RNA load was studied in patients treated with the reverse transcriptase inhibitor …

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

T Shirasaka, MF Kavlick, T Ueno… - Proceedings of the …, 1995 - National Acad Sciences
A set of mutations [Ala-62--> Val (A62V), V75I, F77L, F116Y, and Q151M] in the polymerase
domain of reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) …

The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients

JM Schapiro, MA Winters, F Stewart, B Efron… - Annals of Internal …, 1996 - acpjournals.org
Objective: To evaluate the efficacy and safety of high-dose therapy with the human
immunodeficiency virus (HIV) protease inhibitor saquinavir and to establish the duration of …

Present status and future prospects for HIV therapies

MI Johnston, DF Hoth - Science, 1993 - science.org
Since the discovery of human immunodeficiency virus (HIV) in 1983, significant progress
has been made toward the discovery, development, and licensing of anti-HIV drugs. In vitro …

Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy

RT D'Aquila, VA Johnson, SL Welles… - Annals of internal …, 1995 - acpjournals.org
Objective: To evaluate the association between resistance of human immunodeficiency virus
type 1 (HIV-1) to zidovudine and clinical progression. Design: Retrospective analysis of …